Rationale for the use of dexpanthenol drugs as part of the external therapy of dermatoses in children and adults

Impaired skin barrier plays a major role in the development of many diseases and conditions such as dry skin, sensitive atopic dermatitis, contact etc. The topical therapy aims at not only suppressing inflammatory response but also regenerating destroyed protective epidermal lipid dermatitis patients. Dexpanthenol was produced by synthesis middle last century is derivative pantothenic acid. Topical dexpanthenol well absorbed through where it converted into acid, component coenzyme A, thus participates regulation fatty acids sphingolipids, components stratum corneum. Therefore, acid essential for normal functioning epithelium. improves hydration due to its hygroscopic properties ability retain moisture. hydrating effect interrelated with capacity regenerate skin. enhances differentiation corneocytes synthesis, stimulating regeneration epidermis. Numerous studies show that efficacy comparable glucocorticosteroids weak degree activity. active ingredient Pantoderm, which available cream ointment. Pantoderm ointment contain 5% dexpanthenol. article presents own clinical reports treatment patients administration combination therapy. It may be concluded use combined can increase effectiveness dermatitis.